Abstract: The study goal was to optimize layout of dainage boreholes, and enhance efficiency of drainage boreholes. The study was focus on the law of coal 8# roof aquifer drain in the No.2 north district of Donghuantuo Coal Mine, theoretical analysis was carried out on the water enrichment regularity of aquifers in coal 8th roof under the control of syncline structure. There were 32 boreholes for drainage arranged and six influence indicators. Studied dynamic feature of water vs time and calculated their pearson product-moment correlation coefficient to boreholes water yield. The result was the mining fracture zone would conduct the aquifers above coal 5th; aquifers 0~30 m above coal 5th was drained to decrease its water head of geological structure developed, hydraulic connection was good in the dip direction of stratum, but bad in strike direction. It is appropriate to decorate layout drill socket along the roadway, and to staggered arrangement upper and lower roadway. Borehole location and the initial drainage time during the six influence indicators had most important effects on borehole water yield. The relationship between borehole direction and the fracture strike direction also had significant effect on borehole water yield. Dsigned drainage beginning time should be suitably advance 8 to 10 months.